Influence neutrophil activation peptide nap 2, platelet basic protein, polypeptide iii and activate

Platelet basic protein (penicillin), connective tissue - activating peptide three (ctap - iii), and platelet factor 4 (pf 4)purification from man platelets release supernatant fluid with heparin agarose ion exchange and reversed phase high performance liquid chromatography (HPLC) method, and the influence of neutrophils were compared with those name action plan 2; seven decades polypeptide amino acid sequence of the corresponding part of the penicillin (1) and sequence homology of sodium fluoride/national action plan - 1. Nap - 2 - induced elastase release and increased intracellular ca2 ion concentration between 0.3 and 100 nm, and neutrophils chemotaxis concentration between 0.03 and 10 nano. Half as a powerful and sodium fluoride/national action plan - 1 induced exocytosis but show the same activities in other reaction. By contrast, only the smallest no effect got and penicillin, ctap - iii as high as 100 nm, and factor 4. Name action plan 2 therefore seems like a typical chemotaxis agonist. It can produce penicillin and/or ctap - iii release activated platelet, leading to the accumulation of neutrophils in platelet aggregation.