The current understanding of the regulation of programmed cell death NF-B

Nuclear factor-κB (NF-B) transcription factor has become the main regulatory bodies either through apoptosis or necrosis of programmed cell death (PCD). In this context, the NF-κB activity of having a significant impact, the development of the normal tissue, environmental stability and a variety of cell systems, including the physiological function of the immune, hepatic, epidermal, and nervous system. However, incorrect PCD regulation of NF-B can have serious pathological consequences from neurodegenerative diseases, cancer, their activities are often not effective treatment methods. NF-B is generally protect cells induced apoptosis and antioxidant protein coding genes, and its role in apoptosis and necrosis significantly different in the different environment of the cells, NF-B cell death-inducing stimuli sensitive in some circumstances. This article describes our current knowledge of NF-B in the role of apoptosis and necrosis, and focused a lot of progress since our last review of the oncogene three years ago, the rapid development of the theme. Has made substantial progress in the understanding of the role of NF-B cell apoptosis and necrosis and mechanisms to regulate their anti-apoptotic activity. These recent developments in a number of diseases, including tumor development, tumor progression and anti-cancer effect, NF-B, a new optical flow.